FAM21EP

Across TCGA patient cohorts, FAM21EP mutation is significantly associated with the RNA expression of many other genes, with 1,672 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM21EP-associated genes across cancer lineages are RNU1-1, RNU6-13P, and TNPO1P2. Each is linked with FAM21EP in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM21EP-to-partner and partner-to-FAM21EP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-1 grouped by FAM21EP-low versus FAM21EP-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM21EP→partner) and Y-score (partner→FAM21EP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU1-1 →	+0.426	+4.925	<.001	.004	3	2
UCEC	RNU6-13P →	+0.293	+2.510	<.001	.001	3	2
UCEC	TNPO1P2 →	+0.046	+2.113	.004	.002	3	2
READ	PGBD4P2 →	+0.121	+5.257	<.001	.002	3	1
LUAD	OR51A9P →	+0.170	+4.990	<.001	.009	3	1
LUAD	LINC01923 →	+0.051	+6.197	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,672 associations by consensus.

RNU1-1 by FAM21EP expression — READ

Explore this box plot interactively →