FAM21EP

Across TCGA patient cohorts, FAM21EP mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM21EP-associated genes across cancer lineages are Ku80, Myosin-IIa_pS1943, and N-Ras. Each is linked with FAM21EP in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM21EP-to-partner and partner-to-FAM21EP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by FAM21EP-low versus FAM21EP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM21EP→partner) and Y-score (partner→FAM21EP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.276	+3.598	.015	.001	3	1
UCEC	Myosin-IIa_pS1943 →	+0.231	+2.472	.020	.011	3	1
UCEC	N-Ras →	-0.143	-2.446	.012	.020	3	1
UCEC	AMPK_pT172 →	+0.445	+2.472	.025	.011	3	1
UCEC	Rab25 →	-0.494	-3.000	.002	.036	3	1
UCEC	STAT3_pY705 →	-0.352	-3.169	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Ku80 by FAM21EP expression — UCEC

Explore this box plot interactively →