FAM21EP

Across TCGA pan-cancer cohorts, FAM21EP Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FAM21EP data layer compared with 21 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher FAM21EP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM21EP expression acts as an unfavorable survival marker.

LUSC, UCEC, and LUAD are the cancer types where FAM21EP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.176	0.676	.005	24	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	OS	Median	II,III,IV	0.108	0.677	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FAM21EP–LUSC (OS)

Open the LUSC breakdown →