Q-omics provides the consensus-scored DUSP21 profile across patient tissues and cancer cell-line models. DUSP21 expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, DUSP21 is differentially expressed in 5, with the highest sampling consensus in COAD. Additionally, DUSP21 RNA expression shows 6,454 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight LGG, COAD, and STAD as cancer lineages where DUSP21 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DUSP21 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DUSP21 survival associations across molecular data types. DUSP21 RNA expression shows survival associations in the most cancer types (14), followed by mutation status (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DUSP21 RNA expression–survival associations across cancer types. High DUSP21 expression shows unfavorable associations in LGG, KICH, SCLC, CESC and LUSC, but favorable associations in SKCM. The LGG Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for DUSP21 RNA expression.
This table summarizes DUSP21 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for DUSP21. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DUSP21 shows lower tumor expression in COAD and STAD and higher tumor expression in KIRC, KIRP and PRAD. The COAD box plot shows higher DUSP21 RNA expression in normal versus tumor tissue (log2 FC = −0.370, t-test p < 0.001).
This table shows molecular features associated with DUSP21 in patient tissues and cancer cell lines. In patient samples, DUSP21 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set. In cancer cell lines, DUSP21 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and OVARY.
