Across TCGA patient cohorts, DUSP21 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUSP21-associated genes across cancer lineages are CD31, 14-3-3_beta, and EGFR_pY1068. Each is linked with DUSP21 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUSP21-to-partner and partner-to-DUSP21 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUSP21→partner) and Y-score (partner→DUSP21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD31 →	-0.105	-1.797	.028	.025	3	2
UCEC	14-3-3_beta →	-0.103	-1.880	.001	.014	3	1
UCEC	EGFR_pY1068 →	-0.236	-2.087	.003	.005	3	1
UCEC	EGFR →	-0.137	-1.222	.008	.035	3	1
UCEC	eIF4E →	+0.167	+1.716	.014	.003	3	1
UCEC	eIF4G →	+0.219	+2.459	.029	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Exploration

DUSP21 survival (RNA) · tumor vs normal (RNA) · all DUSP21 data types