DTX2

Across TCGA patient cohorts, DTX2 mutation is significantly associated with the RNA expression of many other genes, with 2,456 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DTX2-associated genes across cancer lineages are TRMT112P1, RPS28P1, and RNA5SP465. Each is linked with DTX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DTX2-to-partner and partner-to-DTX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMT112P1 grouped by DTX2-low versus DTX2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX2→partner) and Y-score (partner→DTX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TRMT112P1 →	+0.040	+3.282	.005	.005	3	3
UCEC	RPS28P1 →	+0.063	+2.568	.008	.005	3	3
SKCM	RNA5SP465 →	+0.445	+2.541	<.001	.002	3	3
LIHC	MIR6796 →	+0.570	+5.268	<.001	.006	3	2
SKCM	SPATA31A5 →	+0.005	+3.009	<.001	.009	3	2
SKCM	AQP7P5 →	+0.123	+2.717	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,456 associations by consensus.

TRMT112P1 by DTX2 expression — SKCM

Explore this box plot interactively →