DTX2

Across TCGA pan-cancer cohorts, DTX2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DTX2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DTX2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DTX2 is over-expressed in tumor.

KIRC, KIRP, and COAD are the cancer types where DTX2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DTX2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.301	<.001	12	view →
KIRP	Male	III,IV	+1.134	<.001	11	view →
COAD	Male	II,III,IV	+0.918	<.001	10	view →
LUAD	Female	III,IV	+1.711	<.001	9	view →
LIHC	Female	II,III,IV	+1.170	<.001	9	view →
THCA	Male	All	+0.477	<.001	8	view →
LUSC	Male	All	+1.067	<.001	7	view →
BRCA	Female	All	+0.581	<.001	6	view →
BLCA	Male	All	+0.794	.002	5	view →
STAD	All	All	+0.877	.002	4	view →
CHOL	Male	All	+2.000	<.001	3	view →
READ	Female	All	+1.607	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DTX2–KIRC

Open the KIRC breakdown →