DTX2

Across TCGA pan-cancer cohorts, DTX2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated DTX2 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DTX2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DTX2 expression acts as an unfavorable survival marker, although some lineages such as THYM and ESCA show a favorable association.

KIRC, LGG, and UVM are the cancer types where DTX2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.508	0.719	<.001	88	view →
LGG	DFS	Median	All	0.633	0.836	<.001	54	view →
UVM	DFS	Median	All	0.384	0.750	.001	48	view →
KIRP	DFS	Quartile	All	0.579	1.000	.004	46	view →
MESO	OS	Quartile	II,III,IV	0.197	0.487	.006	41	view →
ACC	DFS	Tertile	II,III,IV	0.394	0.859	.002	37	view →
LIHC	DFS	Median	All	0.371	0.491	.001	36	view →
PAAD	DFS	Median	All	0.381	0.613	.001	34	view →
THYM	OS	Median	II,III,IV	0.954	0.722	.010	33	view →
KICH	DFS	Quartile	II,III,IV	0.068	1.000	<.001	31	view →
OV	OS	Tertile	All	0.333	0.427	.007	28	view →
ESCA	DFS	Tertile	III,IV	0.582	0.294	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

DTX2–KIRC (DFS)

Open the KIRC breakdown →