Q-omics provides the consensus-scored DEFA5 profile across patient tissues and cancer cell-line models. DEFA5 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, DEFA5 is differentially expressed in 3, with the highest sampling consensus in COAD. Additionally, DEFA5 protein abundance shows 9,966 significant protein co-abundance associations, with the highest sampling consensus in OV. Together, these results highlight LGG, COAD, and OV as cancer lineages where DEFA5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for DEFA5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes DEFA5 survival associations across molecular data types. DEFA5 RNA expression shows survival associations in the most cancer types (16), followed by mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible DEFA5 RNA expression–survival associations across cancer types. High DEFA5 expression shows unfavorable associations in UVM, THCA, UCEC and UCS, but favorable associations in LGG and READ. The LGG Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for DEFA5 RNA expression.
This table summarizes DEFA5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3, while mass-spec protein shows differences in 5. The strongest signals are observed in COAD for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for DEFA5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. DEFA5 shows lower tumor expression in STAD and higher tumor expression in COAD and READ. The COAD box plot shows higher DEFA5 RNA expression in tumor versus normal tissue (log2 FC = +1.748, t-test p = .014).
This table shows molecular features associated with DEFA5 in patient tissues and cancer cell lines. In patient samples, DEFA5 shows the broadest associations at the RNA and protein expression levels, with OV recurring as the lineage with the largest associated feature set. In cancer cell lines, DEFA5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in KIDNEY and BONE.
