DEFA5

Across TCGA pan-cancer cohorts, DEFA5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DEFA5 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DEFA5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DEFA5 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where DEFA5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.480	0.320	.021	21	view →
LSCC	OS	Median	II,III,IV	0.577	0.945	.017	3	view →
LUAD	OS	Tertile	II,III,IV	0.879	0.323	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DEFA5–PDAC (DFS)

Open the PDAC breakdown →