DEFA5

Across TCGA cell cohorts, DEFA5 RNA expression is significantly associated with the go_rna of many other GO terms, with 521 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DEFA5-associated GO terms across cancer lineages are Disruption of cellular anatomical structure in another organism, Disruption of plasma membrane integrity in another organism, and Alpha-beta T cell differentiation. Each is linked with DEFA5 in more than 11 cancer types. Because this analysis shows association rather than direction, both DEFA5-to-partner and partner-to-DEFA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Disruption of cellular anatomical structure in another organism grouped by DEFA5-low versus DEFA5-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA5→partner) and Y-score (partner→DEFA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Disruption of cellular anatomical structure in another organism →	+1.610	+1.171	<.001	.008	3	12
SOFT_TISSUE	Disruption of plasma membrane integrity in another organism →	+1.610	+1.171	<.001	.008	3	12
BREAST	Alpha-beta T cell differentiation →	-0.075	-0.101	.003	.002	3	4
BLOOD_Lymphoma	Transcription pausing by RNA polymerase II →	+0.094	+0.087	<.001	<.001	3	3
BLOOD_Lymphoma	Carbohydrate derivative catabolic process →	-0.028	-0.091	.002	.004	3	3
BLOOD_Lymphoma	Paracrine signaling →	-0.828	-0.105	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 521 associations by consensus.

Disruption of cellular anatomical structure in another organism by DEFA5 expression — SOFT_TISSUE

Explore this box plot interactively →