DEFA5

Across TCGA patient cohorts, DEFA5 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible DEFA5-associated genes across cancer lineages are FKBP4P7, CREB3L2-AS1, and SOCS2P1. Each is linked with DEFA5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DEFA5-to-partner and partner-to-DEFA5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FKBP4P7 grouped by DEFA5-low versus DEFA5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DEFA5→partner) and Y-score (partner→DEFA5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FKBP4P7 →	+0.038	+2.885	<.001	.008	3	1
SKCM	CREB3L2-AS1 →	+0.069	+3.002	.002	.004	3	1
SKCM	SOCS2P1 →	+0.039	+4.039	<.001	.009	3	1
LUAD	OR7E103P →	+0.047	+5.343	.009	.006	3	1
LUAD	RNU6-435P →	+0.481	+5.217	.004	.007	3	1
LUAD	SNORD3H →	+0.273	+5.888	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

FKBP4P7 by DEFA5 expression — SKCM

Explore this box plot interactively →