CDH16

Across TCGA patient cohorts, CDH16 mutation is significantly associated with the RNA expression of many other genes, with 3,170 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH16-associated genes across cancer lineages are PSMD9, UBE2G1, and MAN2B2. Each is linked with CDH16 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDH16-to-partner and partner-to-CDH16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD9 grouped by CDH16-low versus CDH16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH16→partner) and Y-score (partner→CDH16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMD9 →	+0.367	+3.016	.001	<.001	3	3
UCEC	UBE2G1 →	+0.541	+2.463	<.001	.001	3	3
STAD	MAN2B2 →	+0.777	+3.338	<.001	.005	3	3
STAD	AGAP2 →	+0.994	+3.338	<.001	.005	3	3
STAD	DBNDD1 →	+1.413	+3.371	<.001	.004	3	3
STAD	ITGAE →	+0.636	+3.338	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,170 associations by consensus.

PSMD9 by CDH16 expression — UCEC

Explore this box plot interactively →