CDH16

Across TCGA pan-cancer cohorts, CDH16 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CDH16’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CDH16 RNA is repressed in tumor relative to normal tissue. In most cancer types CDH16 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where CDH16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDH16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−2.880	<.001	12	view →
THCA	Male	IV	−6.550	<.001	11	view →
KIRP	Male	All	−2.719	<.001	9	view →
LUAD	Female	II,III,IV	−0.552	<.001	9	view →
KICH	All	II,III,IV	−3.159	<.001	8	view →
LIHC	All	II,III,IV	+1.113	.002	5	view →
UCEC	All	All	−1.142	.045	2	view →
LUSC	Female	All	−0.498	.002	2	view →
COAD	Female	III,IV	−0.428	.002	2	view →
PRAD	All	All	−0.287	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CDH16–KIRC

Open the KIRC breakdown →