CDH16

Across TCGA pan-cancer cohorts, CDH16 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CDH16 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher CDH16 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CDH16 expression acts as an unfavorable survival marker, although some lineages such as KICH and KIRC show a favorable association.

KICH, KIRC, and CESC are the cancer types where CDH16 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	1.000	0.409	.002	71	view →
KIRC	OS	Median	All	0.750	0.527	<.001	59	view →
CESC	DFS	Median	III,IV	0.822	0.561	.003	56	view →
MESO	OS	Median	III,IV	0.289	0.723	.005	27	view →
THYM	DFS	Tertile	All	0.789	0.946	<.001	26	view →
BLCA	OS	Median	II,III,IV	0.341	0.519	.006	23	view →
PAAD	OS	Median	II,III,IV	0.443	0.660	.004	19	view →
ESCA	DFS	Tertile	IV	0.704	0.287	.017	12	view →
GBM	OS	Median	All	0.257	0.510	<.001	12	view →
READ	OS	Median	III,IV	0.975	0.828	.011	10	view →
CHOL	OS	Quartile	All	0.929	0.468	.017	9	view →
HNSC	OS	Tertile	All	0.487	0.291	.013	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CDH16–KICH (DFS)

Open the KICH breakdown →