Q-omics provides the consensus-scored CARNS1 profile across patient tissues and cancer cell-line models. CARNS1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, CARNS1 is differentially expressed in 12, with the highest sampling consensus in THCA. Additionally, CARNS1 RNA expression shows 17,808 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight ACC, THCA, and UVM as cancer lineages where CARNS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CARNS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CARNS1 survival associations across molecular data types. CARNS1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (4) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CARNS1 RNA expression–survival associations across cancer types. High CARNS1 expression shows unfavorable associations in ACC and UVM, but favorable associations in SKCM, MESO, STAD and CESC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for CARNS1 RNA expression.
This table summarizes CARNS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 2. The strongest signals are observed in THCA for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for CARNS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CARNS1 shows lower tumor expression in LUSC, COAD and KIRP and higher tumor expression in THCA, LIHC and CHOL. The THCA box plot shows higher CARNS1 RNA expression in tumor versus normal tissue (log2 FC = +1.083, t-test p < 0.001).
This table shows molecular features associated with CARNS1 in patient tissues and cancer cell lines. In patient samples, CARNS1 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, CARNS1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Leukemia.
