CARNS1

Across TCGA patient cohorts, CARNS1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CARNS1-associated genes across cancer lineages are Rictor_pT1135, p62 Lck ligand, and Cyclin-B1. Each is linked with CARNS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CARNS1-to-partner and partner-to-CARNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by CARNS1-low versus CARNS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CARNS1→partner) and Y-score (partner→CARNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rictor_pT1135 →	-0.078	-1.847	.037	.008	3	3
UCEC	p62 Lck ligand →	+0.252	+1.594	.034	.042	3	2
UCEC	Cyclin-B1 →	+0.591	+3.584	.004	.002	3	2
UCEC	EGFR_pY1068 →	-0.241	-1.502	.009	.030	3	1
UCEC	ERK2 →	+0.261	+2.247	<.001	.001	3	1
UCEC	ETS-1 →	+0.254	+2.459	.030	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Rictor_pT1135 by CARNS1 expression — UCEC

Explore this box plot interactively →