Q-omics provides the consensus-scored CA7 profile across patient tissues and cancer cell-line models. CA7 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, CA7 is differentially expressed in 13, with the highest sampling consensus in COAD. Additionally, CA7 RNA expression shows 11,305 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, COAD, and GBM as cancer lineages where CA7 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CA7 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CA7 survival associations across molecular data types. CA7 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CA7 RNA expression–survival associations across cancer types. High CA7 expression shows unfavorable associations in KIRC, UVM, CESC, ESCA and KIRP, but favorable associations in BRCA. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KIRC as the clearest survival context for CA7 RNA expression.
This table summarizes CA7 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for CA7. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CA7 shows lower tumor expression in COAD, KIRC, READ and STAD and higher tumor expression in THCA and LUAD. The COAD box plot shows higher CA7 RNA expression in normal versus tumor tissue (log2 FC = −6.306, t-test p < 0.001).
This table shows molecular features associated with CA7 in patient tissues and cancer cell lines. In patient samples, CA7 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, CA7 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in STOMACH, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BONE.
