CA7

Across TCGA patient cohorts, CA7 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CA7-associated genes across cancer lineages are MEK1, HER3, and INPP4B. Each is linked with CA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CA7-to-partner and partner-to-CA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CA7-low versus CA7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CA7→partner) and Y-score (partner→CA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.425	+3.169	.034	.020	3	1
UCEC	HER3 →	-0.326	-3.156	.030	.020	1	1
UCEC	INPP4B →	-0.448	-3.156	.011	.020	1	1
UCEC	VHL →	-1.435	-3.169	<.001	.020	1	1
UCEC	Cyclin-B1 →	+0.664	+3.169	.031	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MEK1 by CA7 expression — UCEC

Explore this box plot interactively →