C1q and TNF related 6Genealiases: CTFP6 · CTRP6 · ZACRP6
Q-omics provides the consensus-scored C1QTNF6 profile across patient tissues and cancer cell-line models. C1QTNF6 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, C1QTNF6 is differentially expressed in 16, with the highest sampling consensus in HNSC. Additionally, C1QTNF6 RNA expression shows 17,770 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRP, HNSC, and TGCT as cancer lineages where C1QTNF6 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C1QTNF6 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C1QTNF6 survival associations across molecular data types. C1QTNF6 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (5) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C1QTNF6 RNA expression–survival associations across cancer types. High C1QTNF6 expression shows unfavorable associations in KIRP, UVM, KIRC, MESO and LUAD, but favorable associations in UCEC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for C1QTNF6 RNA expression.
This table summarizes C1QTNF6 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 4. The strongest signals are observed in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for C1QTNF6. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C1QTNF6 shows higher tumor expression in HNSC, BLCA, KIRC, STAD, COAD and KIRP. The HNSC box plot shows higher C1QTNF6 RNA expression in tumor versus normal tissue (log2 FC = +4.040, t-test p < 0.001).
This table shows molecular features associated with C1QTNF6 in patient tissues and cancer cell lines. In patient samples, C1QTNF6 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, C1QTNF6 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and LARGE_INTESTINE.
