chromosome 11 open reading frame 21Genealiases: []
Q-omics provides the consensus-scored C11orf21 profile across patient tissues and cancer cell-line models. C11orf21 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, C11orf21 is differentially expressed in 9, with the highest sampling consensus in KIRC. Additionally, C11orf21 RNA expression shows 15,233 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, KIRC, and LSCC as cancer lineages where C11orf21 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C11orf21 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C11orf21 survival associations across molecular data types. C11orf21 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (2) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C11orf21 RNA expression–survival associations across cancer types. High C11orf21 expression shows unfavorable associations in LGG and DLBC, but favorable associations in HNSC, SKCM, LUAD and LIHC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for C11orf21 RNA expression.
This table summarizes C11orf21 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9, while mass-spec protein shows differences in 4. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for C11orf21. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C11orf21 shows lower tumor expression in LUAD, LUSC, UCEC, BRCA and COAD and higher tumor expression in KIRC. The KIRC box plot shows higher C11orf21 RNA expression in tumor versus normal tissue (log2 FC = +0.774, t-test p < 0.001).
This table shows molecular features associated with C11orf21 in patient tissues and cancer cell lines. In patient samples, C11orf21 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, C11orf21 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in LIVER and BLOOD_Leukemia.
