C11orf21

Across TCGA cell cohorts, C11orf21 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,844 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible C11orf21-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Viral gene expression, and Response to oxygen levels. Each is linked with C11orf21 in more than 6 cancer types. Because this analysis shows association rather than direction, both C11orf21-to-partner and partner-to-C11orf21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by C11orf21-low versus C11orf21-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (C11orf21→partner) and Y-score (partner→C11orf21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.091	+0.035	.003	.002	2	7
BLOOD_Leukemia	Viral gene expression →	+0.043	+1.705	.004	.002	3	6
SOFT_TISSUE	Response to oxygen levels →	+0.059	+0.093	<.001	<.001	3	6
BLOOD_Leukemia	Response to acetaldehyde →	+0.339	+3.074	<.001	<.001	3	5
BLOOD_Leukemia	Cellular response to acetaldehyde →	+0.339	+3.074	<.001	<.001	3	5
SOFT_TISSUE	Regulation of myoblast fusion →	+0.042	+0.076	.004	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,844 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by C11orf21 expression — BREAST

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