C11orf21

Across TCGA pan-cancer cohorts, C11orf21 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated C11orf21 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher C11orf21 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated C11orf21 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

LSCC, PDAC, and UCEC are the cancer types where C11orf21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	0.471	1.000	.016	16	view →
PDAC	OS	Quartile	All	0.868	0.388	.041	2	view →
UCEC	OS	Quartile	All	1.000	0.736	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

C11orf21–LSCC (DFS)

Open the LSCC breakdown →