C11orf21

Across TCGA pan-cancer cohorts, C11orf21 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of C11orf21’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where C11orf21 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types C11orf21 is over-expressed in tumor, although a few such as PDAC and HNSC show the opposite, repressed pattern.

LUAD, PDAC, and HNSC are the cancer types where C11orf21 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in C11orf21 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	+0.996	<.001	8	view →
PDAC	Female	II,III,IV	−1.711	<.001	7	view →
HNSC	All	All	−0.673	.006	6	view →
CCRCC	All	All	−0.728	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

C11orf21–LUAD

Open the LUAD breakdown →