bone morphogenetic protein 8aGenealiases: OP-2 · Op2
Q-omics provides the consensus-scored BMP8A profile across patient tissues and cancer cell-line models. BMP8A expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, BMP8A is differentially expressed in 16, with the highest sampling consensus in HNSC. Additionally, BMP8A RNA expression shows 18,491 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LUAD, HNSC, and UVM as cancer lineages where BMP8A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for BMP8A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes BMP8A survival associations across molecular data types. BMP8A RNA expression shows survival associations in the most cancer types (22), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible BMP8A RNA expression–survival associations across cancer types. High BMP8A expression shows unfavorable associations in KIRC, THCA, LIHC and CESC, but favorable associations in LUAD and UCS. The LUAD Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .004). Together, the overview and detailed table identify LUAD as the clearest survival context for BMP8A RNA expression.
This table summarizes BMP8A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for BMP8A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. BMP8A shows lower tumor expression in THCA and higher tumor expression in HNSC, BLCA, COAD, KIRC and STAD. The HNSC box plot shows higher BMP8A RNA expression in tumor versus normal tissue (log2 FC = +1.291, t-test p < 0.001).
This table shows molecular features associated with BMP8A in patient tissues and cancer cell lines. In patient samples, BMP8A shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, BMP8A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and UPPER_AERODIGESTIVE_TRACT.
