armadillo like helical domain containing 3Genealiases: C10orf76 · DGARM
Q-omics provides the consensus-scored ARMH3 profile across patient tissues and cancer cell-line models. ARMH3 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, ARMH3 is differentially expressed in 12, with the highest sampling consensus in COAD. Additionally, ARMH3 protein abundance shows 21,077 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight KIRC, COAD, and HNSC as cancer lineages where ARMH3 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ARMH3 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ARMH3 survival associations across molecular data types. ARMH3 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (3) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ARMH3 RNA expression–survival associations across cancer types. High ARMH3 expression shows unfavorable associations in ACC, KICH and UVM, but favorable associations in KIRC, SCLC and CHOL. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for ARMH3 RNA expression.
This table summarizes ARMH3 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 8. The strongest signals are observed in COAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for ARMH3. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ARMH3 shows lower tumor expression in COAD, KICH, LUSC, LUAD and BLCA and higher tumor expression in LIHC. The COAD box plot shows higher ARMH3 RNA expression in normal versus tumor tissue (log2 FC = −0.878, t-test p < 0.001).
This table shows molecular features associated with ARMH3 in patient tissues and cancer cell lines. In patient samples, ARMH3 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, ARMH3 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and UPPER_AERODIGESTIVE_TRACT.
