Regulation of store-operated calcium entry

Across TCGA cell cohorts, RNA activity of the Regulation of store-operated calcium entry pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMAD9, LITAF, and RASL10B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of store-operated calcium entry activity versus SMAD9 in SOFT_TISSUE (Pearson r = -0.89).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SMAD9 →	-2.137	-0.339	.009	.006	3	4
OVARY	LITAF →	+2.830	+1.792	.009	<.001	3	3
BREAST	RASL10B →	-2.130	-1.864	.007	<.001	3	3
OVARY	GJB4 →	+1.806	+1.748	.001	<.001	3	3
OVARY	UAP1L1 →	-2.106	-1.792	.008	<.001	3	3
OVARY	SRRT →	-1.330	-1.849	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001256 vs SMAD9 — SOFT_TISSUE

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