Positive regulation of chromosome organization

Across TCGA patient cohorts, RNA activity of the Positive regulation of chromosome organization pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSF1_S397, TOP2A_S1247, and NUF2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chromosome organization activity versus RSF1_S397 in PDAC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RSF1_S397 →	+0.890	+0.043	.001	<.001	3	8
LUAD	TOP2A_S1247 →	+1.173	+0.044	<.001	<.001	3	8
GBM	NUF2 →	+0.953	+0.059	<.001	<.001	3	8
HNSC	RIF1 →	+0.493	+0.097	<.001	<.001	3	7
GBM	SETDB1_S1066 →	+1.048	+0.070	<.001	<.001	3	7
GBM	SMC4 →	+0.931	+0.055	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2001252 vs RSF1_S397 — PDAC

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