GO:2000609Ontology (GO BP)GO biological process · ~7 member genes
Q-omics provides the Regulation of thyroid hormone generation (GO:2000609) pathway profile, scoring each patient from the combined activity of its roughly 7 member genes. Pathway activity is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 16, with the highest sampling consensus in KIRC. Additionally, pathway RNA activity shows 28,223 significant cross-omics associations, again with the highest sampling consensus in KIRC. Together, these results highlight BLCA, and KIRC as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Regulation of thyroid hormone generation survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (26). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Regulation of thyroid hormone generation activity shows favorable associations in BLCA, BRCA, LGG, THCA and UVM, but unfavorable associations in TGCT. In the BLCA Kaplan–Meier curve the low-activity group declines faster, consistent with the favorable association (log-rank p = .001). BLCA ranks highest by sampling consensus for Regulation of thyroid hormone generation.
This table summarizes Regulation of thyroid hormone generation tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 16 cancer types, while mass-spec protein activity shows differences in 4. The strongest signals are in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across COAD, UCEC and BRCA and lower tumor activity in KIRC, KIRP and KICH. In the KIRC box plot, normal samples show higher pathway activity than tumor samples (log2 FC = −0.204, t-test p < 0.001).
This table shows molecular features associated with Regulation of thyroid hormone generation pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in KIRC. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in LARGE_INTESTINE.
