Regulation of thyroid hormone generation

Across TCGA cell cohorts, RNA activity of the Regulation of thyroid hormone generation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFAB1, FUT6, and CKS1B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDUFAB1 grouped by Regulation of thyroid hormone generation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NDUFAB1 →	+0.390	+1.070	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	FUT6 →	+0.326	+1.557	.002	.003	2	4
UPPER_AERODIGESTIVE_TRACT	CKS1B →	+0.240	+1.291	.001	.003	3	3
OESOPHAGUS	EZH2 →	-0.176	-1.001	.002	.008	3	3
OESOPHAGUS	RAN →	-0.280	-1.069	.001	.004	3	3
LIVER	SDHB →	-0.187	-1.474	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDUFAB1 by Regulation of thyroid hormone generation activity — BREAST

Explore this box plot interactively →