Regulation of thyroid hormone generation

Across TCGA cell cohorts, RNA activity of the Regulation of thyroid hormone generation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRNKL1, FAM98C, and ZNF697, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRNKL1 grouped by Regulation of thyroid hormone generation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CRNKL1 →	+0.749	+0.755	.001	.007	3	4
BONE	FAM98C →	-0.997	-1.282	.001	.002	3	4
BONE	ZNF697 →	+1.024	+1.252	.004	.001	3	4
PANCREAS	RAE1 →	+0.692	+1.198	.002	.003	3	4
BREAST	LSM1 →	+0.780	+0.729	.003	.001	3	4
OVARY	CYB5D1 →	+0.994	+1.413	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRNKL1 by Regulation of thyroid hormone generation activity — BREAST

Explore this box plot interactively →