Regulation of thyroid hormone generation

Across TCGA patient cohorts, RNA activity of the Regulation of thyroid hormone generation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUOXA1, ILF2P1, and PDCD2L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of thyroid hormone generation activity versus DUOXA1 in HNSC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DUOXA1 →	+1.087	+0.309	<.001	<.001	3	4
UCEC	ILF2P1 →	-0.538	-0.405	.001	.001	3	4
PDAC	PDCD2L →	-0.596	-1.710	<.001	<.001	3	4
HNSC	GCOM1 →	+0.850	+0.291	<.001	.001	3	3
LUAD	EPHA2 →	+0.751	+0.198	.005	.007	3	3
HNSC	S100A12 →	+1.628	+0.268	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000609 vs DUOXA1 — HNSC

Explore this scatter interactively →