Positive regulation of protein neddylation

Across TCGA patient cohorts, RNA activity of the Positive regulation of protein neddylation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNB1, PCK1, and SNHG12, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein neddylation activity versus LMNB1 in CCRCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LMNB1 →	+0.528	+0.126	<.001	.009	3	3
CCRCC	PCK1 →	-2.140	-0.133	.005	.008	3	3
CCRCC	SNHG12 →	+0.468	+0.094	.001	.003	3	3
BRCA	RPS15AP12 →	+1.207	+0.461	<.001	.008	3	3
UCEC	LURAP1L →	-0.527	-0.303	.006	.003	3	3
BRCA	FBXO34 →	-0.602	-0.636	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000436 vs LMNB1 — CCRCC

Explore this scatter interactively →