Positive regulation of protein neddylation

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein neddylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDST2, SUPT7L, and TDP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NDST2 grouped by Positive regulation of protein neddylation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NDST2 →	-1.095	-1.092	<.001	.001	3	4
LUNG_SCLC	SUPT7L →	-0.564	-1.254	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	TDP2 →	-0.962	-1.214	<.001	.009	3	3
UPPER_AERODIGESTIVE_TRACT	APPL2 →	-1.546	-1.232	<.001	.008	3	3
UPPER_AERODIGESTIVE_TRACT	THAP5 →	-1.068	-1.211	<.001	.009	3	3
BONE	SART3 →	-1.685	-2.271	.006	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NDST2 by Positive regulation of protein neddylation activity — BREAST

Explore this box plot interactively →