Regulation of protein neddylation

Across TCGA patient cohorts, RNA activity of the Regulation of protein neddylation pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B, EEF2_T57, and LMNB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein neddylation activity versus MAP1B in LUAD (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MAP1B →	+0.483	+0.030	.004	<.001	3	6
HNSC	EEF2_T57 →	-0.401	-0.074	<.001	.005	3	5
CCRCC	LMNB1 →	-0.209	-0.038	<.001	<.001	3	5
CCRCC	AP2A1 →	+0.233	+0.058	<.001	<.001	3	5
BRCA	NID2 →	+0.327	+0.031	<.001	<.001	3	5
LUAD	MAP1B_S91 →	+0.549	+0.028	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000434 vs MAP1B — LUAD

Explore this scatter interactively →