Regulation of protein neddylation

Across TCGA cell cohorts, RNA activity of the Regulation of protein neddylation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAP30, ATP5F1D, and WRAP53, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein neddylation activity versus SAP30 in SOFT_TISSUE (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SAP30 →	+1.401	+2.068	.006	<.001	3	5
SOFT_TISSUE	ATP5F1D →	+0.543	+1.564	.002	.005	2	6
URINARY_TRACT	WRAP53 →	+1.505	+1.979	<.001	.007	3	5
BREAST	EXOSC9 →	+0.565	+1.115	.001	.001	3	5
LIVER	HNRNPD →	+0.920	+2.340	.002	.002	3	5
LIVER	POM121 →	+1.046	+2.327	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000434 vs SAP30 — SOFT_TISSUE

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