Positive regulation of myoblast proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEIS2, CDIN1, and PPARD, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myoblast proliferation activity versus MEIS2 in SOFT_TISSUE (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MEIS2 →	+2.229	+0.145	<.001	<.001	3	15
URINARY_TRACT	CDIN1 →	+0.676	+0.149	.006	<.001	3	8
OVARY	PPARD →	+1.026	+0.402	<.001	.001	3	6
URINARY_TRACT	CORO2A →	+1.433	+0.098	.006	.009	3	5
LARGE_INTESTINE	CHN1 →	-1.231	-0.094	.002	.002	3	5
BONE	FAM149A →	-1.656	-0.159	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000288 vs MEIS2 — SOFT_TISSUE

Explore this scatter interactively →