Positive regulation of myoblast proliferation

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of myoblast proliferation pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in stomach adenocarcinoma (STAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as STAD and BRCA, show the opposite pattern, with lower activity in tumor tissue.

STAD, BRCA, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
STAD	All	II,III,IV	−0.071	<.001	9	view →
BRCA	All	III,IV	−0.057	<.001	6	view →
LUSC	Female	II,III,IV	+0.102	.003	4	view →
KIRC	Male	All	−0.015	.011	3	view →
UCEC	All	All	−0.072	.001	2	view →
PRAD	All	All	−0.046	<.001	2	view →
LUAD	Female	III,IV	−0.032	.015	2	view →
THCA	Male	All	+0.042	.045	1	view →
LIHC	Female	II,III,IV	+0.036	.049	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:2000288–STAD

Open the STAD breakdown →