Regulation of non-canonical Wnt signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of non-canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GREM2, PLEKHA4, and PRICKLE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of non-canonical Wnt signaling pathway activity versus GREM2 in OV (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GREM2 →	+0.767	+0.595	<.001	<.001	3	5
OV	PLEKHA4 →	+0.839	+0.441	.001	.002	3	4
HNSC	PRICKLE1 →	+0.625	+0.306	.002	.008	2	5
HNSC	UQCRH →	-0.874	-0.267	.009	.009	3	4
HNSC	TYMS →	-0.596	-0.323	.001	<.001	3	4
HNSC	TRAIP →	-0.536	-0.224	.003	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000050 vs GREM2 — OV

Explore this scatter interactively →