Adaptive thermogenesis

Across TCGA patient cohorts, RNA activity of the Adaptive thermogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HOXC-AS2, RPL7P19, and HOXC-AS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adaptive thermogenesis activity versus HOXC-AS2 in BRCA (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HOXC-AS2 →	+0.946	+0.168	.001	.004	3	3
UCEC	RPL7P19 →	+1.378	+0.298	<.001	.001	3	3
LUAD	HOXC-AS1 →	+1.085	+0.231	.002	.001	3	3
PDAC	ZNF257 →	-0.495	-0.119	.003	.009	3	3
HNSC	ZNF649-AS1 →	+0.495	+0.132	.002	<.001	3	3
UCEC	C11orf21 →	-0.592	-0.233	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990845 vs HOXC-AS2 — BRCA

Explore this scatter interactively →