Negative regulation of lipid localization

Across TCGA cell cohorts, RNA activity of the Negative regulation of lipid localization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMAN2L, LTA4H, and PFKFB3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LMAN2L grouped by Negative regulation of lipid localization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	LMAN2L →	+0.811	+1.280	.004	<.001	3	5
OVARY	LTA4H →	-0.814	-1.160	<.001	<.001	3	4
BLOOD_Lymphoma	PFKFB3 →	-1.082	-1.586	.005	.003	3	4
LUNG_SCLC	WDR88 →	+0.196	+0.994	.008	.006	3	4
PANCREAS	LSM2 →	+0.677	+0.945	.004	<.001	3	4
LARGE_INTESTINE	THEM5 →	+0.294	+0.871	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LMAN2L by Negative regulation of lipid localization activity — SOFT_TISSUE

Explore this box plot interactively →