Negative regulation of lipid localization

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of lipid localization pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 60 member genes.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher Negative regulation of lipid localization pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and BRCA, show the opposite pattern, with higher activity associated with better survival.

SKCM, STAD, and BRCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	II,III,IV	0.890	0.788	<.001	89	view →
STAD	DFS	Median	All	0.306	0.479	.002	43	view →
BRCA	OS	Median	III,IV	0.692	0.449	.001	26	view →
GBM	OS	Median	All	0.276	0.501	.005	25	view →
READ	DFS	Tertile	III,IV	0.527	0.183	.002	24	view →
THCA	DFS	Median	All	0.950	0.702	.001	23	view →
HNSC	DFS	Median	IV	0.752	0.587	.007	16	view →
KIRC	DFS	Tertile	IV	0.309	0.710	.001	16	view →
PCPG	OS	Median	All	0.938	1.000	.023	12	view →
UCS	OS	Quartile	III,IV	0.362	0.757	.020	12	view →
UCEC	OS	Tertile	IV	0.277	0.642	.030	12	view →
MESO	OS	Tertile	IV	0.787	0.246	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:1905953–SKCM (OS)

Open the SKCM breakdown →