Cranial skeletal system development

Across TCGA patient cohorts, RNA activity of the Cranial skeletal system development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRNDE, CCRL2, and ASGR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial skeletal system development activity versus CRNDE in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CRNDE →	+0.708	+0.615	.001	.001	3	5
UCEC	CCRL2 →	-0.574	-0.739	.002	.001	3	4
UCEC	ASGR2 →	-0.394	-0.611	.003	.001	3	4
BRCA	HCAR2 →	-0.891	-0.691	.008	.001	3	4
LUAD	CASP5 →	-0.474	-0.604	.003	.001	3	4
LUAD	ZNF226 →	+0.337	+0.580	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904888 vs CRNDE — GBM

Explore this scatter interactively →