Q-omics provides the consensus-scored CRNDE profile across patient tissues and cancer cell-line models. CRNDE expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, CRNDE is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, CRNDE RNA expression shows 19,120 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight ACC, KIRC, and KIRP as cancer lineages where CRNDE shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CRNDE — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CRNDE survival associations across molecular data types. CRNDE RNA expression shows survival associations in the most cancer types (27). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CRNDE RNA expression–survival associations across cancer types. High CRNDE expression shows unfavorable associations in ACC, LGG, KIRC and GBM, but favorable associations in LUAD and KIRP. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for CRNDE RNA expression.
This table summarizes CRNDE tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for CRNDE. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CRNDE shows lower tumor expression in KICH and higher tumor expression in KIRC, COAD, KIRP, LIHC and READ. The KIRC box plot shows higher CRNDE RNA expression in tumor versus normal tissue (log2 FC = +1.400, t-test p < 0.001).
This table shows molecular features associated with CRNDE in patient tissues and cancer cell lines. In patient samples, CRNDE shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set.
