CRNDE

Across TCGA pan-cancer cohorts, CRNDE RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CRNDE’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CRNDE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CRNDE is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where CRNDE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRNDE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.400	<.001	12	view →
COAD	Female	All	+2.325	<.001	11	view →
KIRP	All	II,III,IV	+1.518	<.001	9	view →
LIHC	Male	II,III,IV	+1.760	<.001	8	view →
READ	Female	All	+2.642	<.001	7	view →
KICH	Female	II,III,IV	−2.531	<.001	7	view →
THCA	All	All	+0.511	<.001	6	view →
BRCA	All	II,III,IV	+0.398	.003	6	view →
STAD	All	All	+0.867	.007	3	view →
PAAD	All	All	+2.387	.011	2	view →
CHOL	All	All	+2.073	<.001	2	view →
BLCA	All	All	+1.121	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CRNDE–KIRC

Open the KIRC breakdown →