CRNDE

Across TCGA pan-cancer cohorts, CRNDE RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CRNDE data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CRNDE RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CRNDE expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRP show a favorable association.

ACC, LUAD, and KIRC are the cancer types where CRNDE RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.247	0.674	<.001	102	view →
LUAD	OS	Median	All	0.756	0.614	<.001	102	view →
KIRC	OS	Median	All	0.764	0.853	.003	54	view →
LGG	DFS	Median	All	0.611	0.860	<.001	54	view →
KIRP	OS	Median	All	0.972	0.890	.002	33	view →
GBM	DFS	Median	All	0.187	0.324	<.001	30	view →
THCA	OS	Quartile	II,III,IV	0.771	1.000	.005	26	view →
UCEC	OS	Quartile	II,III,IV	0.901	0.773	.024	26	view →
LIHC	OS	Quartile	All	0.640	0.818	.007	25	view →
PRAD	DFS	Median	All	0.847	0.919	.007	20	view →
LAML	DFS	Quartile	All	0.799	0.436	.006	18	view →
THYM	OS	Quartile	All	0.948	0.780	.016	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CRNDE–ACC (DFS)

Open the ACC breakdown →