Regulation of phospholipid metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of phospholipid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC34, LINC00570, and LMNB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phospholipid metabolic process activity versus CCDC34 in LUAD (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CCDC34 →	-0.527	-0.103	<.001	.005	3	5
GBM	LINC00570 →	+0.159	+0.178	<.001	<.001	3	4
BRCA	LMNB1 →	-0.829	-0.166	<.001	<.001	3	4
BRCA	DEPDC1B →	-0.721	-0.162	<.001	<.001	3	4
LSCC	SPC25 →	-0.752	-0.170	.004	<.001	3	4
GBM	PLEKHA8 →	-0.310	-0.246	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903725 vs CCDC34 — LUAD

Explore this scatter interactively →