Regulation of attachment of mitotic spindle microtubules to kinetochore

Across TCGA patient cohorts, RNA activity of the Regulation of attachment of mitotic spindle microtubules to kinetochore pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, SETDB1_S1066, and SMC4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of attachment of mitotic spindle microtubules to kinetochore activity versus RRM2 in LUAD (Pearson r = 0.71).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RRM2 →	+0.963	+0.153	<.001	<.001	3	9
LUAD	SETDB1_S1066 →	+1.031	+0.144	<.001	<.001	3	9
GBM	SMC4 →	+0.752	+0.141	<.001	<.001	3	9
LUAD	TOP2A →	+1.186	+0.152	<.001	<.001	3	9
LUAD	TOP2A_S1106 →	+1.293	+0.144	<.001	<.001	3	9
LUAD	KIF11_T926 →	+1.157	+0.140	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1902423 vs RRM2 — LUAD

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