Alpha-amino acid metabolic process

Across TCGA cell cohorts, RNA activity of the Alpha-amino acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SHPK, HIF1A, and MRPL48, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SHPK grouped by Alpha-amino acid metabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SHPK →	+0.556	+0.140	.009	.005	3	4
OVARY	HIF1A →	-1.502	-1.132	.007	<.001	3	4
PANCREAS	MRPL48 →	+0.725	+0.245	.003	.001	3	4
SKIN	POLR2E →	-0.560	-0.873	.003	.002	3	3
LUNG_SCLC	BCL2L1 →	-1.124	-0.204	<.001	<.001	3	3
CNS	NME6 →	-0.479	-0.654	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SHPK by Alpha-amino acid metabolic process activity — OESOPHAGUS

Explore this box plot interactively →