Alpha-amino acid metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Alpha-amino acid metabolic process pathway differs between tumor and matched normal tissue in 12 of the 18 cancer types tested.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KIRP and KICH, show the opposite pattern, with lower activity in tumor tissue.

KIRP, KICH, and LIHC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KIRP	Male	All	−0.058	<.001	11	view →
KICH	Female	II,III,IV	−0.072	<.001	8	view →
LIHC	Female	All	−0.049	<.001	8	view →
LUAD	Male	All	+0.024	<.001	8	view →
KIRC	Male	All	−0.023	<.001	7	view →
COAD	All	II,III,IV	+0.014	<.001	7	view →
BRCA	All	All	−0.017	<.001	6	view →
LUSC	All	All	+0.016	<.001	6	view →
CHOL	Male	All	−0.145	<.001	5	view →
STAD	Male	All	+0.019	.011	4	view →
THCA	Female	All	−0.013	<.001	2	view →
PRAD	All	All	+0.007	.031	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 12 lineages.

GO:1901605–KIRP

Open the KIRP breakdown →